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Image Search Results
Journal: Cell Communication and Signaling : CCS
Article Title: Retinoic acid enhances γδ T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion
doi: 10.1186/s12964-025-02161-8
Figure Lengend Snippet: Low retinoic acid levels are associated with high Tim-3 expression in patients with NPC. A Magnetic resonance imaging (MRI) scans depicting tumor sizes in patients with primary NPC (II, III, and IV). B Serum RA levels in healthy donors (HD, n = 40) and NPC ( n = 65) patients. C Graphical representation of RA levels in the serum of NPC patients stratified by stage (II, n = 18; III, n = 21; IV, n = 26). D RA levels in NPC patients categorized by EBV status (EBV-, n = 39; EBV + , n = 26). E , F Correlations between RA levels and immune marker expression on circulating αβ (CD4 + and CD8 + T cells, n = 65) and γδ T cells (Vδ1 + and Vδ2 + T cells, n = 43). G-J Correlation analysis of Tim-3 and CD28 on circulating T cells (CD8, n = 65; Vδ2, n = 43) with RA levels in NPC patients. Two-tailed unpaired Student's t-test was employed in panels ( B and D ); while one-way ANOVA with Tukey’s multiple comparison test was applied in panel ( C ). Spearman correlation coefficients were calculated for panels ( E - J ). Data are presented as the mean ± SD. Significance was indicated as follows: * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, n.s. , not significant
Article Snippet: When the tumor volume reached to approximately 50–100 mm 3 , tumor-bearing mice were intraperitoneally injected with 25 μg/mouse AGN194310 (RARi; MCE, HY-16681), 2.5 mg/kg
Techniques: Expressing, Magnetic Resonance Imaging, Marker, Two Tailed Test, Comparison